Clinical Analysis and Follow-up of 20 Cases of Congenital Gonadai Dysgenesis / 第二军医大学学报

ABSTRACT

This paper reports clinical and cytogenetic studies on 20 cases of congenital ovary dysgenesis (Turner syndrome). The clinical studies included the history, physical and pelvic examinations, blood FSH, LH and estradiol determinations, and pneumoperitoneography, Cytogenetic studies on the karyotype of lymphocytes were performed with G,C banding and high resolution chromosome banding techniques. There were karyotypes with 45,X in 12 cases,46, XX/45,X in 2 cases, 45,X/46,XX/46,XXp- in 2 cases, 45, X/46,Xi (Xq) in 2 cases,45,X(Xqace) in one case and 46,Xi(Xq) in one case. One of these patients (46,XX/45,X) had a term pregnancy, and a girl has grown well. Treatment was mainly low-dose estrogen replacement therapy with cyclic administration of progesterone. These patients were followed up from four months to 20 years. Six of them were married with normal sexual activity. The patients' height was increased by 2 to 10 cm after treatment. It is concluded that the supporting treatment is beneficial whenever the diagnosis is made.