Changes of Beta-adrenergic Receptors and cAMP-PDE Activity of Asthmatic Lung Tissue in Guinea Pigs / 第三军医大学学报

ABSTRACT

The changes of the number of beta-adrenergic receptors, the activity of cAMP-PDE and the level of cAMP were observed in the guinea pigs with allergic asthma with radioligand assay, radioenzyme assay and radioimu-noassay respectively. It was found that there were a 25% decrease of the number of beta-adrenergic receptors on the lung membrane, a 36% decrease of the level of cAMP in the lung tissue, and a 35% increase of cAMP-PDE activity in the asthmatic animals as compared with those of the control. A close positive correlation was observed between the number of beta-adrenergic receptors and cAMP level,but a negative correlation between cAMP-PDE activity and cAMP level in the asthmatic group.