Antimutagenic Effects of 17 Compounds / 第二军医大学学报

ABSTRACT

The inhibitory and antimutagenic effects of 17 compounds, cysteine (1), cinnamic acid (2), rutin (3), tannic acid (4), germanium dioxide (5), fluro uracil (6), sodium copper chlorophylline (7), B-sitosterol (8), vitamin C (9), coumarin (10), vitamin E (11), L-glutathione (oxidized form) (12), L-glutathione (reduced form) (13), sodium selenile (14), organic germanium (15), L-methioine (16) and proline (17) on the SOS response induced by N-methyl-N'-nitro-N-nitrosoguanidine, niethly muthanesulfonate, benzo (a)pyrine and UV were studied by using SOS chromotest. The results showed that compounds 1~15 revealed inhibitory effects, and compounds 2~8 and 10-11 revealed antimutagenic effects. It was demonstrated that cinnamic acid is the best antimutagen among 17 compounds. Cinnamic acid has not only inhibitory effect but also antimutagenic activity towards a wide variety of mutagens/carcinogens. The modes, specificity and end point of action of antimutagens are discussed.