ANTI-INFLAMMATORY EFFECT OF TOTAL ALKALOID OF LEONTICE KIAGNANENSIS AND ITS MECHANISM OF ACTION / 中国药理学通报

ABSTRACT

The anti-inflammatory of waterand fat-soluble alkoloids of Leon-tice Kiagnanensis (WSALK, FSALK ) were described after sc of WSALK (150, 300 mg/kg ) and FSALK (13, 26mg/kg ) . The increased capillary permeability in abdominal cavity and skin of mice induced respectively by 0.7% HAc and histamin were inhibited abviously. WSALK (75, 150, 300mg/kg, ip ) and FSALK (6.5, 13, 26mg/Kg, ip ) markedly inhibited the ear inflammation induced by xylene in mice, carrageenin-iaduces swelling of the ankle in normal on adrenalecto-mized rats, and carrageenin-induced pleurisy in rats. Both compound also inhibited the granuloma induced by cotton pellet after sc of WSALK 300, 600 mg/kg and FSALK 13, 26 mg/kg qd ? 7d.Both compound decreased the content of PGE in exudate formed after injecting carrageenin into the hind paw of rats. These results suggest that both compounds passesses the anti-inflammatory activity and their actions might be relatied to their inhibiting the synthesis or relase of pro-staglandin E. WSALK TI 9.35, FSALK TI 4.50.