PROTECTIVE EFFECT OF PHENCYCLIDINE ON ACUTE CEREBRAL ISCHEMIA OF RABBIT-ANALYSIS OF BETA- ENDORPHIN IMMUNOREACTIVITY IN CEREBROSPINAL FLUID / 中国药理学通报

ABSTRACT

Acute cerebral ischemia and reperfusion injury of rabbits was produced by permanently occluding the vertebral arteries and temporarily clamping the common carotid arteries for 30 min. Beta-endorphin immunoreactive substance ( ir beta-endorphin ) content were measured in cerebrospinal fluid at pre-ischemia and after ischemia and reperfusion stages. In control group, the content of ir beta-endorphin significantly increased (1.01?0.52 mg/L, P