Experimental studies on enhancing effect of aloperine upon PG-cyclooxygenase activity / 中国药理学通报

ABSTRACT

Experimental studies were made on enhancing effect of aloperine on PG-cyclooxyge-nase activity. Radioimmunoassay for determination of PGE2 and PGF2? contents was employed to evaluate PG-cyclooxygenase activity. Mice were given aloperine (50mg ? kg ? d-1) ip for 7d and the effects of lung and kidney homogenates on extrogenous arachidonic acid were studied. The results suggest that biosynthesis of PGE2, PGF2? be obviously increased in the experimental than that of control, suggesting of aloperine showing enhancing effect on PG-cyclooxygenase activity.