Effects of bepridil, nimodipine and nicardipine on the activity of CaM dependent protein kinase Ⅱ from mouse cerebrum in vitro / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1986.
Article
in Zh
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| ID: wpr-550915
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ABSTRACT
The effects of bepridil, ni-modipine and nicardipine on the activity of CaM - dependent protein kinase Ⅱ from mouse cerebrum were studied in vitro. Tt was found that bepridil significantly inhibitied the activity of CaM - PK Ⅱ with an IC50 value of 0. 3 mmol ? L-1. but nimodipine and nicardipine did not basi-cally influence the activity of the enzyme. The experimental results showed that the inhibitory effect of bepridil on the activity of CaM - PK Ⅱ was an antagonistic action of bepridil to CaM.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article