Observation on cardiovascular function and oxygen transport during hemorrhagic shock at 4 000 m altitude in dogs / 第三军医大学学报

ABSTRACT

Dogs were bled and maintained at the mean arterial pressure(MAP)of 6.67 kPa(moderate shock)or of 5.33 kPa(severe shock)for 2 hours.Then the blood shed was transfused back to the animals and observation on the dogs was carried on for 2 more hours.26 mongrel dogs,weighing 10~16 kg,were randomized into Group I of normoxia and moderate shock(NMS,n=7),Group I of normoxia and severe shock(NSS,n=7).Group I of hypoxia at a simulated alti- tude of 4 000 m and moderate shock(HMS,n=6),and Group IV of hypoxia and severe shock(HSS,n=6).The changes of the cardiovascular function and the oxygen transport were observed in these animals after anesthetization.It was found that the cardiovascular function was similar in HMS and NMS groups.The decrease of VO2 of HMS animals was similar to that of NSS dogs.Decompensation occurred earlier in HSS animals and resulted in high mortality.