Effects of Kupffer's cell activity on traping of plasmodial sporozoites and on their passing through hepatic sinus walls / 第三军医大学学报

ABSTRACT

The effects of Kupffer's cells on the traping or killing of the plasmodial sporozoites and on the transporting of them through the hepatic sinus walls into the Disse's space were summarized.The phagocytosis of Kupffer's cells plays an important role to trap the sporozoites and the ability to trap sporozoites is higher in the liver than in the lungs and the spleen.In general,the stronger the phagocytosis of the Kupffer's cells,the more advantageous to the invasion of sporozoites;the higher the biocidal activity of Kupffer's cells,the more advantageous for the host to prevent the sporozoites from invading.When the biocidal activity of the Kupffer's cells is enhanced by certain drug agents,more sporozoites can be phagocytized and killed and less amounts of sporozoites will invade the host's red cells.