Adhesive-hemostatic effect and toxicity of 3?-cyanoacrylic esters / 第三军医大学学报

ABSTRACT

It was found that citrated rabbit blood in a test tube could be coagulated within 5 seconds after the addition of isobutyl ?-cyanoacrylate.isoamyl ?-cyanoacrylate and isobutyl ?-cyanoacrylate glycolate in different concentrations respectively.All these monomers exhibited quick and reliable styptic effect on the hemorrhage of the liver,the spleen and the kidneys of rabbits and rats respectively,and their styptic effect was superior to that of most conventional hemostatics.The test for their acute toxicity revealed that they were of quite low toxicity and their dosage for adhesive-hemostatic purpose was about one gram.There was no evident injurious effect on the functions of the kidneys and the liver and the peripheral hemogram in rabbits.The test for subacute toxicity revealed no obvious pathological changes but some imflammatory responses over the site of drug application.