Study of cellular and subcellular damages and their patho-genesis in septic shock in rats / 第三军医大学学报

ABSTRACT

The changes of hepatocyte and skeletal muscle membrane potential.the membrane fluidity of microsomes,microviscosity.and the order coefficient of the arrangement of membrane lipid molecules were determined in rats after their cecum was ligated and punctured to induce septic shock.Lipid peroxides of plasma and the liver,phospholipase A2 and salivary acid were determined as well.It was found that both in the first 10 hours and the next 20 hours of septic shock,the resting membrane potential of hepatocytes and skeletal muscles was significantly suppressed as compared with that of the sham-operated rats.The membrane potential of hepatocytes was suppressed prior to the decrease of blood pressure and much earlier and much more severe than that of skelatal muscles.Lipid peroxides of the liver were increased by 1.6 fold(P