Effects of intracere broventri cular injection of L-proline on learning and memory in mice / 中国药理学通报

ABSTRACT

In step-down tests in mice,the effects of L -proline 0.1 - 100?g ? mouse-1 icv on memory acquisition were not observed, but L -proline0. l~10?g ? mouse-1 icv could significantly improve the anisodine- induced impairments of memory acquisition. This effect of L-proline 1?g ? mouse-1 icv could not be antagonized with D-2-amino-5-phosphonovaleric acid(APS), the N-methyl-D-aspartate (NMDA) receptor antagonist. L-proline 1?g ? mouse-1 icv could also improve memory acquisition impairment induced by high GABA level in brain. This results suggested that L - proline may improve the memory as the modulator or possibly through GABA.