A study on antigen receptor gene rearrangements in 13 cases of T-cell non-Hodgkin's lymphoma / 第三军医大学学报

ABSTRACT

The beta and gamma chain gene rearrangements of the T-cell receptors(TCR)were studied with Southern blot hybridization and polymerase chain reaction in 13 cases of non-Hodgkin's lymphoma with T-cell phenotype.It was found that 11 out of the 13 cases(86%)exhibited TCR beta gene rearragnement and 12 out of the 13(91%)displayed TCR gamma gene rearrangement.The findings suggest that gene rearrangements are more sensitive and specific markers to establish T-cell monoclonality and lineage and helpful to the morphological diagnosis and immunophenotyping for non-Hodgkin's lymphoma.