Antihypertensive effect of 3,6-di (dimethylamino) dibenzopyriodonium fromate (IHC-64) / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-551207
ABSTRACT
The blood pressure of conscious and anaesthetized animals feel significantly after iv IHC-64. IHC-64 acts rapidly but the time of acts was short. No acute tolerance was observed. After iv IHC-64 0. 5 and 1. 5 mg?kg-1 in anaesthetized dogs the blood pressure feel immediately, lasted for 12?5 min and 30 min . After iv IHC-64 0. 75,1. 5 and 3. 0 mg?kg-1in anaesthetized rabbits the blood pressure fell within 0. 5~ 1.0 min and the time of acts was re-spectively 10?5 min,12?7 min and 19?11 min . Antihypertensive effect of IHC-64 was more powerful than that of Clonidine and was similar to Sodium Notroprusside. The dosage of antihypertensive effect didn't affect the heart rate of conscious rabbits and anaesthetized dogs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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