Anti-inflammatory Effect of High-dose Glucocorticoid and Its Mechanism during Cardiopulmonary Bypass in Rabbits / 第二军医大学学报

ABSTRACT

The effect of high-dose glucocorticoid (GC) on plasma phospholipase A2 (PLA2) activity, extravascular lung water (EVLW) and lung pathology during cardiopulmonary bypass (CPB) was studied on the CPB model in rabbits. The results showed that both plasma PLA2 activities and EVLW increased significantly during CPB, and there was a significant correlation between EVLW and plasma PLA2 activities at 90 min of CPB (r = 0. 8439, P