Anti-arrhythmia and anti-lipid peroxidation effect of Quinidine and Cimetidine / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-551289
ABSTRACT
The content of malondialdehyde (MDA) , a metabolite of lipid peroxide (LPO) , in plasma and tissue homongenate from rabbits with arrhythmias induced by adrenaline (Adr) was determined. The results showed that the MDA level was increased in plasma and tissue homogenate. Quinidine (Qui) 6 mg ? kg-1, Cimetidine (Cim) 37. 5 mg?kg-1, and 1/2 dose of both drugs administered intravenously couldsignificantly prevent ventricular arrhythmias induced by Adr and inhibit the production of MDA. The findings suggest that the effect of Qui and Cim on arrhythmias induced by Adr may associate with its inhibition on lipid peroxi-dation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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