The significance of congenital small nevus in the pathogenesis of malignant melanoma / 第三军医大学学报

ABSTRACT

There are controversies concerning whether congential small nevus(CSN)is liable to undergo malignant degeneration and whether it should be resected promptly.The signif-icane of CSN in the pathogenesis of malignant melanoma(MM)was assessed with microspec-trophotometric determination of DNA quantity,the detection of the gene product of N-ras,p21 protein,with ABC technique,ultrastructural study of MM tissue with electron microscopy,and analysis of clinical data of MM.The findings were as follows(1)The DNA content increased sequentially in order of acquired nevus(AN),CSN,congenital giant nevus(CGN)and MM,and the difference was statistically significant among the 4 groups(P