P53 Gene Mutations in Human Seminomas Screened by Using Polymerase Chain Reaction Technique / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1985.
Article
in Chinese
| WPRIM
| ID: wpr-551318
ABSTRACT
Genomic DNA from 17 primary human tcsticular seminomas was screend for the presence of mutations in exon 5 - 8 of P53 gene, using the single strand conformation polymorphism assay, followed by direct DNA sequencing. P53 mutations in one alle'e leading to an amino acid change were identified in 4 of 17 seminomas. Sites of mutations were in exon 5(codon 141), exon 7 (codon 238, codon 258) and exon 8(codon 279). The present study suggests that mutation of P53 gene is involved in the development of human testicular seminoma.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
1985
Type:
Article
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