DNA — anti — DNA IMMUNE COMPLEXES ENHANCE IL— 6 PRODUCTION BY MOUSE MESANQIAL CELLS / 中华肾脏病杂志
Chinese Journal of Nephrology
;
(12)1994.
Article
in Chinese
| WPRIM
| ID: wpr-551393
ABSTRACT
Using the IL—6 dependent hybridoma cell line KD83, we investigated the relationship between KNA—anti—DNA immune complexes(DNA—anti—DNAICs)from the sera of lupus nephritis patients and interleukin 6 (IL—6) production by mouse glomerular mesangial cells cultured in vitro. The results show that DNA—anti—DNA IgM and DNA—anti—DNA IgG and DNA—anti—DNA IgM all enhance IL—6 production by mesangial cells; of those DNA—anti—DNA IC, the effect of DNA—anti—DNA IgM on IL—6 production by mesangial cells was significant. This enhanced production of IL—6 by mesangial cells was dependent on concentration of DAN—anti—DNA ICs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Nephrology
Year:
1994
Type:
Article
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