Long term efficacy of partial splenic embolization for thalassanemia major / 中华放射学杂志

ABSTRACT

Objective To evaluate the long term efficacy of partial splenic embolization(PSE) for thalassanemia major. Methods 75 patients with thalassanemia major were treated with PSE and followed for 5 years,in which 30 patients with compelete data were studied.There were 8 patients with ? thalassanemia major,22 patients with ? thalassanemia major.The follow up indices included mean haemoglobin concertration,transfusion indices and blood transfusion consumption after embolization at 1,2,3,4,5 years. Results 26 of 30 patients showed a reduction in blood transfusion requirements and increase in haemoglobin level after embolization. The median blood transfusion requirements decreased from 1 200 ml/year before embolization to 200 ml/year; and the transfusion indices dropped from 6 times/year to 1 time/year. The mean of haemoglobin level increased from (60 9? 18 9)g/L to (82 3?17 4)g/L. The total effective rate was 86 7%,in which ? ,? thalassanemia major were 100 0%,81 8% respectively. Conclusion PSE is an effective therapeutic procedure for thalassanemia major, especially for ? thalassanemia major.