RELATION BETWEEN THE CHANGE IN NITRIC OXIDE SYNTHASE(NOS)IN GASTRIC MUCOSA INDUCED BY PHYSICAL STRESS OR PSYCHOLOGICAL STRESS AND ACUTE GASTRIC MUCOSAL LESION IN RATS / 解放军医学杂志

ABSTRACT

To explore the relation between the changes in nitric oxide synthase in gastric mucosa induced by physical stress and psychological stress and acute gastric mucosal lesion,Animal model was reproduced with impulsive stimulator of high voltage and stable currency.Ninety-six male SD rats were randomly divided into three groupscontrol, regular and irregular group.NOS activity was measured by spectrophotometry,and the degree of injury of gastric mucosa was measured by method of Nils Lambecht.Immunohistochemistry and polyantibodies of NOSⅠ,NOSⅡ,NOSⅢ were employed to investigate locations of NOS.The result showed that NOS activity was stable in normal rats but increased significantly in group of psychological stress( P