SPECTROSCOPIC DIFFERENTIATION BETWEEN NORMAL LUNG TISSUE AND LUNG CANCER BY LASER INDUCED AUTO FLUORESCENCE / 解放军医学杂志

ABSTRACT

To obtain the criterion of Laser induced Autofluorescence (LIF) spectroscopy in the differentiation of normal lung tissue and lung cancer and study the feasibility of LIF spectroscopy in the diagnosis of lung cancer, the LIF spectra of normal lung and lung cancer in 42 surgical specimens have been measured with a detecting system which consists of an YAG laser(wavelength 355nm) and an optical multichannel analyzer(OMA). Spectroscopic differences between normal lung and cancerous tissues have been found which could be used as a criterion to distinguish from them . The pathological examinations were done to compare with the criterion. The results showed① The location of the principal spectral peaks of the normal lung tissue (470.8?6.3)nm and lung cancer ( 463.7 ?4.8)nm are different( P