MRI study of bone marrow in aplastic anemia / 中华放射学杂志

ABSTRACT

Objective To evaluate the MRI in the diagnosis of aplastic anemia (AA) and MRI changes after therapy. Methods MR imaging of lumber spine in 16 patients with AA proved pathologically were performed on 0.5 T superconductive MR unit with T 1WI, T 2WI, and STIR, slice thick 5 mm, slice gap 1 mm, matrix 180?256. Thirty cases of normal volunteers were examined as control group. Lumber spines of the two groups were studied by observation of MRI findings, measurement of the T 1 relaxation value. In AA group, the percentage of the hypointense signal areas in the centrum was calculated. Results Three patterns were classified by MR appearance in lumber spine of our cases. MR findings of pattern 1 (2 cases) were hyperintense on T 1WI, isointense on T 2WI, and hypointense on STIR, and all two cases were acute aplastic anemia (AAA). In pattern 2 (7 cases), a few irregular hypointense signals appeared in the background of hyperintense signal on all 3 sequences, and 5 of them were AAA. Pattern 3 (7 cases) demonstrated mixed irregular shape of hyperintense and hypointense signals, all 7 cases were chronic aplastic anemia (CAA). The percentage of the area of hypointense signal in AAA was significantly smaller than that in CAA (t=30 00, P