The expression of TGF ? receptor Ⅰ and apoptosis in gastric carcinoma and precancerous lesions / 中国实用内科杂志

ABSTRACT

Objective To investigate the relationship between the expression of TGF ? receptor Ⅰ(RⅠ)and apoptosis in gastric carcinoma and precancerous lesions,and their effects in the development of gastric carcinoma.Methods The expressions of TGF ?RⅠ in 103 cases,including CSG(30 cases),IM(30 cases),Dys(18 cases)and GAC(25 cases)were detected by immunohistochemical techniques(SP),apoptosis cells were examined by terminal deoxynucleotidyl transferase(TdT) mediated dUTP nick end labelling(TUNEL).Results Both the expressions of TGF ?RⅠ and apoptosis indexes(AIpercentage of TUNEL positive cells)showed negative correlation with the degree of gastric mucosa lesions from CSG,IM,Dys to GAC(r=-0^7272,P