VACCINATION OF ALLOGENEIC DENDRITIC CELLS IN THE TREATMENT OF ACUTE MYELOID LEUKEMIA / 解放军医学杂志

ABSTRACT

To investigate the safety, efficacy and feasibility of the administration of a number of DCs from HLA identical donor in the treatment of leukemia. Peripheral blood mononuclear cells (PBMNCs) of HLA identical healthy donors were collected. PBMNCs were cultivated initially with IL 4,hGM CSF,TNF ?, and stimulated by lysate of leukemic cells.Dendritic cells were induced and given to the patients. The response of the patients to the infusion of DCs was observed. Clinical observation showed that the progress of leukemia was limited partly. There was no toxicity directly referable to this treatment. It is feasible and safe to generate and administer DCs pulsed with tumor lysate, suggesting that it could be a potential treatment for advanced acute myeloid leukemia.