A STUDY ON PROMOTION OF REVASCULARIZATION BY INTRAARTERIAL ADMINISTRATION OF ANGIOGENIN IN A RABBIT LIMB ISCHEMIC MODEL / 解放军医学杂志

ABSTRACT

To study the effect of intraarterial bolus of recombinant human angiogenin (rhANG) on stimulating revascularization in a rabbit hindlimb ischemic model,the limb ischemic model was induced by ligation and excision of every branches of the femoral artery in 28 rabbits. On the 11th day after operation, various doses of rhANG (0,5,20 and 40 ? g) as a single bolus were administered intraarterialy via the catheters inserted into the bifurcation of the iliac artery. Revascularization and perfusion of the ischemic limb were compared in each animal postoperatively by using 99 Tc MAA perfusion scan, serial angiography and thigh muscle biopsy. Rabbits in the 20?g group and the 40?g group had significantly better revascularization and blood perfusion than the control group and the 5?g group.It is concluded that rhANG can promote blood purfusion, revascularization and recovery.