THE INHIBITORY EFFECT OF OCTREOTIDE ON THE PROLIFERATION AND EXPRESSION OF ENDOGENOUS GF-I IN VSMCs / 解放军医学杂志

ABSTRACT

The effects of octreotide on DNA synthesis and the expression of endogenous insulin like growth factor I(IGF I)in newborn calf vascular smooth muscle cells(VSMCs) in vitro were analysed with 3 H thymidine incorporation and immunocytochemistry respectively.Concentration over 1 nmol/L of octreotide inhibited the increasing of 3 H thymidine incorporation induced by serum and IGF I in VSMCs. Serum and IGF I could stimulate the synthesis of endogenous IGF I in VSMCs.When cultured with 10 nmol/L of octreotide,the gray value of IGF I rose 16 0% and 13 3% respectively.It is suggested that octreotide can inhibit DNA synthesis induced by serum and IGF I in VSMCs,and the expression of endogenous IGF I in VSMCs.