THE EFFECT OF PERICARPIUM ARECAE ON GASTRIC ELECTRO ARRHYTHMIA IN RATS AND ITS MECHANISMS / 解放军医学杂志

ABSTRACT

To study the effect of pericarpium arecae on gastric electro arrhythmia in rats and its mechanisms, 30 Wistars were randomly divided into 3 groups control group, model group and pericarpium arecae plus model group.The frequency of slow wave, coefficient of variation (CV) and abnormal rhythm index (ARI) were recorded and analyzed by computer, meanwhile the cholinergic and nitrigic nerves in antral myoenteric plexus were observed with histochemical staining. The results showed that, compared with control group, the CV and ARI in model group markedly increased ( P 0 05) after treatment with pericarpium arecae; the density of cholinergic nerves markedly decreased( P 0 05) after treatment with pericarpium arecae. It suggested that pericarpium arecae has regulative effect on the gastric electro arrhythmia in rats, and the increased cholinergic nerves and decreased nitrigic nerves in antral myoenteric plexus may be its underlying mechanisms.