Pharmacokinetic study on flomoxef in healthy volunteers / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)1981.
Article
in Chinese
| WPRIM
| ID: wpr-552778
ABSTRACT
Objective:
To study the pharmacokinetics of f1omoxef(Fmox) in 8 hea1thy volunteers after infusion of 1 gFmox injection.Methods:
Fmox concentrations in plasma and urine were measured by an improved HPLC method.Results:
The results showed that peak plasma level (cmax), terminal phase plasma elimination half-life (t1/2?), volume of distribution(Vc ), clearance (CI3)and area under plama concentration-time curve (AUC)were (56.15?13.16) ?g/ml, (1.29?0.32) h,(13. 11?12. 06) L, (16.02?1.88) L/h and (64.86?4.93)?g? h/ml respectively.Conclusion:
Drug concentrations-time pro-file of Fmox conforms to a two-compartment open phartnacokinetic model. Fmox is mainly excreted through kidney in un-changed form. The cumulative urinary excretive rate of Fmox is (79. 39l4. 01) % 8 h after administration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
1981
Type:
Article
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