Observation on serology and histology of patients with chronic hepatitis B after interferon treatment / 中华传染病杂志

ABSTRACT

Objective To investigate the changes in serology and liver histology of patients with chronic hepatitis B after interferon treatment. Methods Twenty four patients with chronic hepatitis B were enrolled in this research. Sera of patients were obtained before and after interferon treatment respectively. Liver biopsy was performed in each patient before and after treatment respectively. Serum ALT, HBsAg, HBcAg, HBeAg, HBV DNA and TIMP 1 were evaluated, as well as HAI(histological activity index), HBsAg, HBcAg, HBeAg, TIMP 1 and activated HSC in liver. Results The patients responded to interferon accounted for 7/24(37.5%). Compared with pretreatment, the serum HBV DNA and TIMP 1 decreased significantly( P