IMPACTS OF HIGH SALT INTAKE PLUS COLD STRESS ON CARDIAC RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN RATS / 解放军医学杂志

ABSTRACT

To study the effects of high salt intake together with cold stress on rat cardiac renin angiotensin aldosterone system (RAAS) in rats. Male Wistar rats were randomly divided into four groups control, high salt (8%NaCl), cold stress (5 2℃) and compound group (8%NaCl+cold stress). Blood pressure and body weight were measured once a week. The experiment ran for 8 weeks. Renin activity (RA), angiotensinⅡ (AngⅡ), and aldosterone (Aldo) in plasma and left ventricle were determined with radioimmunoassay. Angiotensin II receptor mRNA was determined with RT PCR. The results showed that ①Rats in compound group had higher blood pressure than rats in the other three groups ( P