Hepatitis B and C virus infection in uremia patients on chronic hemodialysis / 中国实用内科杂志

ABSTRACT

Objective To investigate the hepatitis C virus(HCV) and hepatitis B virus(HBV) infection in hemodialysis patients in several hemodialysis centers in Beijing.Methods HCV RNA,HBV DNA(PCR) and the serum virus antibody(ELISA) were detected in 225 uremia patients.50 volunteers and the employers in hemodialysis center were also as controls.The relationship between the infection of hepatitis virus and the dialysis time,blood infusion and hepatic function was analysed.Results 37 patients(16.4%) were positive in HCV RNA,3 patients(1.33%) positive in HBV DNA.The logistic analysis showed that blood infusion and the time of hemodialysis were the risk factors.3 patients(3/99,3.0%) were found to be infected with both hepatitis B and C,with disorder of liver function and clinical symptoms.8.1%(8/99) of patients with positive HBcAb were infected with HCV.Conclusion The prevalence of HCV infection in hemodialysis patients is serious.Hemodialysis time and times of blood transfusion are the major ways to transmit HCV.