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Evaluation of the Automated Hematology Analyzer Sysmex XN-2000 and the Accuracy of Differential Leukocyte Counts Using the Low WBC Mode
Laboratory Medicine Online ; : 188-195, 2015.
Article in Korean | WPRIM | ID: wpr-55298
ABSTRACT

BACKGROUND:

The XN-series (Sysmex, Japan) is the new hematology analyzer from Sysmex, with new channels to improve the accuracy of differential leukocyte count and platelet count in the low cell count range. We evaluated the analytical performance and low white blood cell (WBC) mode of the XN-2000.

METHODS:

Precision, linearity, and carryover were evaluated for the analyzer. We analyzed the accordance of complete blood count (CBC), reticulocyte count, and differential leukocyte count between the XN-2000 and XE-2100 (Sysmex), using 200 samples from normal controls and patients. For 80 samples with a WBC count 0.9800 for all CBC parameters except mean corpuscular hemoglobin concentration, mean platelet volume, and platelet distribution width, and >0.9900 for differential leukocyte count except monocytes and basophils. The low WBC mode provided accurate counts for neutrophils and lymphocytes, with r>0.9300 for samples with a WBC count of 0.1-1.5x10(9) cells/L.

CONCLUSIONS:

The XN-2000 showed good analytical performance and correlation with the existing model, the XE-2100. The XN-2000 provided accurate results for differential leukocyte count in samples with a WBC count of 0.1-1.5x10(9) cells/L, and reduced manual slide reviews.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Platelet Count / Basophils / Blood Cell Count / Blood Platelets / Lymphocytes / Monocytes / Cell Count / Reticulocyte Count / Erythrocyte Indices / Mean Platelet Volume Limits: Humans Language: Korean Journal: Laboratory Medicine Online Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Platelet Count / Basophils / Blood Cell Count / Blood Platelets / Lymphocytes / Monocytes / Cell Count / Reticulocyte Count / Erythrocyte Indices / Mean Platelet Volume Limits: Humans Language: Korean Journal: Laboratory Medicine Online Year: 2015 Type: Article