Angiogenesis and dynamic contrast enhanced MRI of benign and malignant breast lesions: preliminary results / 中华放射学杂志

ABSTRACT

60%) MR early-phase enhancement rate and time-SI curve type Ⅱ and Ⅲ showed an association with increased MVD and higher VEGF expression level. All the differences mentioned above showed statistical significance except that the difference between VEGF expression and the distribution of curve types had no statistical significance. No significant relationships were observed between the mean of enhancement amplitude and MVD or VEGF expression. Regarding the distribution of MVD, the study showed that the greater MVD was most frequently observed at the marginal region of breast cancer, although the distribution of MVD was heterogeneous in each lesion. Conclusion MVD and VEGF affect the contrast medium enhancement of breast lesions. The early-phase enhancement rate and time-SI curve types of benign and malignant breast lesions are closely related to MVD and VEGF. As a noninvasive method, contrast enhanced MRI has a potential role in estimating the degree of angiogenesis of breast neoplasm.