DEVELOPMENT OF AN EXPERIMENTAL MODEL OF TRAUMATIC SHOCK IN RATS / 解放军医学杂志

ABSTRACT

To establish a standard experimental model of traumatic shock in rats that could not only imitate clinical features,but also be performed easily, multiple injuries involving the leg bones,the soft tissue and hemorrhage in Sprague Daulay rats were made by hitting its legs on both sides with a 2500g pontil falling from 30cm height to induce traumatic shock. Resuscitated the rats after 90 minutes and monitored the vital signs,and then calculated the 24 hour and 72 hour death rates. There were about (7 8?1 6) minutes of the rats from injury to shock. The death rates were 27 5% in 24 hours and 52 5% in 72 hours. This model has been proved to be relatively simple,stable and basically closed to clinical features of traumatic shock, so it is a reliable,acute animal model for experimental study of traumatic shock.