Effects of cilostazol on plasma platelet-related indicators in trauma fractures patients with postoperative venous thrombosis / 中国生化药物杂志

ABSTRACT

Objective To evaluate the effects of cilostazol on plasma platelet-related indicators in trauma fractures patients with postoperative venous thrombosis.Methods 104 cases of trauma fractures patients with postoperative venous thrombosis from February 2012 to July 2013 in Laiwu City People’s Hospital were collected and randomly divided into group A and group group B,each had 52 cases Two groups were given conventional nursing, and group A were added cilostaeol group B were added aspirin.Other 50 cases of current healthy people for medical examination were selected for controls (group C).The effects of cilostazol on plasma platelet-related indicators in each treatment group were analyzed. Result Before treatment,the levels of IL-6 and IL-8 in group A and B were significantly higher than group C(P<0.01),but there is no difference between group A and B.The plasma CRP, FIB and DD in group A and B were significantly decreased than group C(P<0.01,P<0.05).After appropriate treatment,the levels of CRP,FIB and DD in group A and B were significantly reduced than pre-treatment(P<0.01,P<0.05).CRP content in group A was lower than that in group B,the difference was statistically significant(P<0.05 ),FIB and DD in group A showed no differencewith group B.Before treatment,PDW,PLT,MPV and P-LCR in group A and B were significantly higher than group C(P<0.01,P<0.05).After appropriate treatment,the levels of PDW,PLT,MPV and P-LCR in two groups were significantly decreased (P <0.01,P <0.05 ),but there was no difference between two groups.Before treatment,the expression of platelet activation in group A,B were significantly higher than group C(P<0.01),but significantly reduced after appropriate treatment (P<0.01),and the difference between the two groups was not statistically significant.Conclusion Cilostazol could reduce the expression of inflammatory factors,levels of D-dimer and fibrinogen and platelet related indicators by reduced platelet activation,which plays antithrombotic effect.