THE CHANGE IN DENSITY AND FUNCTION OF ? AND ?_3 ADRENOCEPTORS IN INSTABLE RAT BLADDER / 解放军医学杂志

ABSTRACT

To investigate the role of ?and ? 3 adrenoceptors(? 3 AR) in rat detrusor instability secondary to bladder outflow obstruction(BOO). Animal models of detrusor instability were replicated in female rats, the relaxation response produced by ISO and ? 3 AR agonists BRL37344A were examined by means of in vitro detrusor strip study. ? and ? 3 adrenoceptors were detected in bladder specimens with radioligand binding assay. The concentrations of ISO and BRL37344A to produce relaxation were different in normal, stable and instable groups. There was a significant decrease in the density of ? adrenoceptors in the instable group compared with the controls and the stable group (66 23?6 39, 85 85?7 53, and 81 36?6 72 fmol/mg protein, respectively) ( P