EFFECTS OF LPS, TNF-?, IL-1? ON CYCLOOXYGENASE-2 EXPRESSION IN RAT POLYMORPHONUCLEAR LEUKOCYTES / 解放军医学杂志
Article
in Zh
| WPRIM
| ID: wpr-553552
Responsible library:
WPRO
ABSTRACT
To explore the effects of lipopolysaccharide (LPS), TNF ? and IL 1? on cyclooxygenase 2 (COX 2) expression and prostaglandins (PGs) in rat polymorphonuclear (PMN), measured COX 2 mRNA was determined by reverse transcription polymerase chain reaction and changes in PGs after stimulation of PMN with LPS, TNF ? and IL 1? for 24 hours were observed. The resting PMN were found to express COX 2 mRNA weakly, while it was significantly up regulated after the stimulation of LPS,TNF ?and IL 1?. The level of PGs was increased markedly at the same time. These results suggested that COX 2 might play an important role during inflammatory process involving PMN.
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Index:
WPRIM
Language:
Zh
Journal:
Medical Journal of Chinese People's Liberation Army
Year:
1983
Type:
Article