The change of BNP and hs-CRP levels in coronary heart disease patients with heart failure / 中国基层医药

ABSTRACT

Objective To investigate the relationship between coronary heart disease patients with heart fail -ure and natriuretic peptide ( BNP) and c-reactive protein ( hs-CRP) ,and provide the clinical basis .Methods 160 cor-onary heart disease patients with heart failure were selected as the observation group ,and 200 health individuals as the control group .The BNP and hs-CRP with heart failure were analyzed .Results BNP and hs-CRP of the observation group were(481.5 ±57.8)pg/mL and(12.4 ±2.9)mg/L,which were higher than that of the control group [(41.2 ± 9.6)pg/L vs(3.8 ±1.1)mg/L],the difference was statistically significant (t=13.17,5.28,all P<0.05);Left ven-tricular ejection fraction(LVEF)of the observation group was (41.9 ±6.3)%,lower than that of the control group (60.2 ±8.4)%,the difference was statistically significant (P<0.05);BNP and hs-CRP of grade Ⅰ,Ⅱ,Ⅲ and Ⅳincreased with the grade ,the differences were statistically significant ( t=5.20,10.11,12.42,4.18,5.02,3.98,all P<0.05);By Logistic analysis,serum BNP and hs-CRP were associated with heart failure of coronary heart disease . Conclusion Coronary heart disease patients with heart failure cardiac function were associated with BNP and hs -CRP,and with grade were gradually increasing that BNP and hs-CRP increased.