The relationship between dexamethasone and expression of brain derive neurotrophic factor and its receptor gene in experimental bacterial meningitis / 中华传染病杂志
Chinese Journal of Infectious Diseases
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-553762
ABSTRACT
Objective To investigate the relationship between dexamethasone and brain derive neurotrophic factor gene in experimental bacterial meningitis. Methods To construct the models of bacterial meningitis in 3 weeks old rats(n=33),then 23 of them were administed antibiotic and antibiotic plus dexamethasone respectively. BDNF mRNA and TrkB mRNA in brain was detected by in situ hybridization methods,respectively. Results After administration antibiotics, the expression of BDNF mRNA and TrkB mRNA in brain tissue were less than that in brain after infection 5 d(P 0.05), the expression of TrkB mRNA was stronger than that in brain at 5 d after infection(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Infectious Diseases
Year:
2000
Type:
Article
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