Study on pathway of apoptosis in chronic liver disease / 中华传染病杂志

ABSTRACT

Objective To study the pathway of apoptosis occurred in chronic liver diseases. Methods Liver biopsy specimens from 72 cases of chronic hepatitis and 29 cases of post-hepatitis cirrhosis were studied. The appoptosis related proteins, including Fas、FasL、Bax、Bcl-2、Bcl-X L and Bcl-2? were examined immunohistochemically by SP method. Ultrastructures of liver cells from 15 cases with apoptosis were studied with attention to the mitochondrial changes. Results In the chronic hepatitis group, the positive rates of expression of Fas、FasL、Bax were higher than in Bcl-2、Bcl-X L 、Bcl-2? with statistical significance (P