Progress in the animal models of Alzheimers disease / 中国药理学通报

ABSTRACT

Alzheimers disease (AD) is a progressively and retrogressively neurodegenerative disorder characterized by two hallmarks senile plaques (SP) and neurofibrillary tangles (NFTs). The studies of animal models, which are crucial to the further study of AD, will promote the understanding of the etiology, mechanisms and medicine screening. Although the animal models such as experimental injury, normal aging and compound types could represent the cognitive deficit, they lack the essential neuropathological characteristics of AD. Senescence accelerated mouse / prone 8 is one of relatively practical and stable models. The most enchanting focus of AD models is transgenic mice that provide new carriers for the research of pathogenic forms of specific genes and metabolites thereof in vivo. As therapies of AD evolve from symptomatic treatment to causative treatment,so must the animal models of AD.