Effects of ligustrazine on serum CGRP and on the expression of CGRP,PDGF and bFGF in lung of hypoxic rats / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 237-1999.
Article
in Chinese
| WPRIM
| ID: wpr-554055
ABSTRACT
OBJECTIVE:
To study the effects of ligustrazine on the SCGRP and on the expression of CGRP,PDGF and bFGF in the lung of CHPH rats.METHOD:
A stable rat modle of CHPH was established.The serum CGRP levels were mesured by enzyme immunoassay.The expression of CGRP,PDGF and bFGF in lumg were observed by immunohistochemical method.RESULTS:
①The SCGRP level of H group was significantly lower than that of N group (P<0.01) but no difference between the H+Li group and H group (P>0.05).②The expression of CGRP,PDGF and bFGF increased obviously in lung tissue of H group,whereas the expression of bFGF and PDGF of H+Li group reduced obviously but that of CGRP was not influenced.CONCLUSION:
SCGRP reduction and expression increasion increasion of PDGF.bFGF have close relation with the formation of CHPH;Inhibiting the expression of PDGF.bFGF may be an aspect of the mechanism of preventing and treating HPH by ligustrazine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
1999
Type:
Article
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