Effects of astragalus polysaccharide (APS) on murine bone marrow and spleen progenitor cells in MMC-induced myleosuppression / 中国药理学通报

ABSTRACT

AIM To observe the effect of APS on bone marrow and spleen progenitor cells in MMC induced myelosuppression in mice. MEHTODS MMC 7 mg?kg -1 was injected ip on day 0, APS 100 mg?kg -1 ?d -1 was given sc in 3 regimens ① on day 0～4, ② on day 0～11,③ 12 doses in 3 weeks. RESULT APS increased the number of bone marrow progenitor cells(CFU C) of MMC treated mice 3 fold, from 1 870 ?40 per femur to 6 240 ?110 per femur on day 3.APS treatment resulted in a higher level of bone marrow CFU C at all time points from day 3 to day 18, in comparison with the control group. APS also significantly stimulated the proliferation of spleen progenitor cells on day 14 (3 fold of control) and day 18(2 fold of control) after MMC treatment, however APS had no effect on spleen progenitor cells before day 14. CONCLUSION These results demonstrate that APS enhances the proliferation and maturation of the progenitors of peripheral blood cells in MMC treated mice.