Experimental study of zhi-chuan-ling oral liquor on asthma / 中国临床药理学与治疗学

ABSTRACT

AIM: To evaluate its pharmacodynamic effects of zhi-chuan-ling (ZCL) oral liquor, a traditional Chinese medicinal prescription, on asthma. METHODS: Asthma models of guinea pigs were established by aerosol inhalation of mixed solution of histamine and acetylcholine for the observation of effects of ZCL on the latent period of asthma attack. Some other indices were also investigated including the contraction of smooth muscle strips isolated from the trachea or intestinum ileum, and variations of the tracheal volume and the bronchotracheal perfusion in guinea pigs. RESULTS: ZCL elongated the latent period of asthma attack induced by areol inhalation of mixed solution of histamine and acetylcholine, antagonized activities against the contraction of the trachea and intestinum ileum induced by histamine or acetlcholine, and increased the tracheal volume and the bronchotracheal perfusion in ginea pigs in vitro. CONCLUTION ZCL can reduce airway hyperresponsibility, relax bronchospasm, remit ventilation disturbance, and improve ventilatory function by its biologic activities against acetlcholin and histamine.