Effects of total flavones metasequosia on ischemia reperfusion injury in guinea pig working heart / 中国药理学通报

ABSTRACT

AIM To investigate the effects of t ot al flavones metasequosia (TFM) on ischemia reperfusion injury in guinea pig work ing heart. METHODS Ischemia reperfusion injury model was used to evaluate the effects of TFM. Myocardial func tion, the content of CK、LDH and the activity of MDA were measured. RESU LT TFM improved the cardiac function, decreased the release of LDH and CK and inhibited the increase of MDA content. CONCLUSION TFM had a protective effect on ischemia reperfusion injury of myocardium which could be re lated to its inhibitory effect on lipid peroxidation.