Effects of apomorphine hydrochloride on the sexual function of rats / 中国药理学通报

ABSTRACT

AIM To study the effects of apomorphine hydrochloride on the sexual function of rate. METHODS Male rats were grouped at random and respectively intraperitoneally injected with different dosages of apomorphine hydrochloride (4 32, 2 16 and 1 08 mg?kg -1 ), These male rats were put into cages respectively with a female rat to conduct the copulation experiment,including the latent periods of their seizure and ejaculation and the times of their seizing of the female rats and ejaculation within twenty minutes on the first and the eighth day during the injection. Radioimmunoassay(RIA) was used to determine the contents of luteinizing hormone(LH) ,prolactin(PRL) ,testosterone(T) and estradiol(E 2) in the venous blood on the fourth and the eighth day during the injection. RESULTS Apomorphine hydrochloride(4 32 and 2 16 mg?kg -1 ) can significantly increas the copulatory capability of male rats on the first and the eighth day during the injection, obviously reduce the latent periods of their seizing of the female rats and ejaculation when male and female rats were caged together, and increase the times of their seizure and ejaculation within twenty minutes after being caged together,but it had no obvious effects on the contents of luteinizing hormone(LH), prolactin (PRL), testosterone(T) and estradiol(E 2) in the venous blood. CONCLUSION Apomorphine hydrochloride can significantly increase the sexual function of male rats.