Pirh2 and tumor / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 824-826,880, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-554177
ABSTRACT
Pirh2 (p53-induced protein with a Ring-H2 domain),one of the ubiquitin-protein E3 ligases,can promote p53 degradation via ubiquitin-proteasome pathway,and repress the biological functions of p53.Researchers have found that the Pirh2 is overexpressed in many cancers,which suggests Pirh2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2012
Type:
Article
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