Nocturnal Hypercalciuria for Enuresis Subtypes: Prospective Controlled Study / 대한비뇨기과학회지

ABSTRACT

PURPOSE: The aim of this study was to determine whether the enuresis subtype, on the basis of nocturnal hypercalciuria, can be generally accepted. MATERIALS AND METHODS: Since 2003, 58 children visited our clinic for nocturnal enuresis, and were enrolled in this study. Patients were followed to evaluate the treatment response after three months medical treatment. Patients were divided into 3 groups; group 1 had nocturnal polyuria, group 2 had non-nocturnal polyuria and group 3 did not have nocturnal enuresis. The urine creatinine, osmolarity and calcium were measured in urine obtained both during the day and night. Hypercalciuria was defined as a urinary calcium to urinary creatinine ratio greater than 0.20. The treatment response was measured as a full, partial or non-response in the nocturnal hypercalciuria and non-nocturnal hypercalciuric groups. Statistical evaluation was performed using Pearson correlation, chi-squared, Student's t-test (paired) and ANOVA tests. RESULTS: There were no significant differences in the calciuria to urinary creatinine ratios between the groups in the urine obtained during the night. There were no significant differences in urinary Ca/kg/12 hours between the groups, with the exception of a significant increase at night in group 1. There were no statistically significant correlations between nocturnal polyuria and nocturnal calciuria between the three groups. During the 3 months after medical therapy, there were no significant differences in the response rates between the nocturnal hyperclaciuria and non-nocturnal hypercalciuria groups. CONCLUSIONS: In this study, no evidence could be for hypercalciuria affecting nocturnal polyuria, including the treatment response results. Therefore, as the first diagnostic method of enuresis, the hypercalciuria measurement can not be recommended. Further study is necessary to classify the enuresis subtype on the basis of nocturnal hypercalciuria.