RELATIONSHIP BETWEEN GASTROINTESTINAL HORMONES AND GASTROINTESTINAL DYSMYOTONIA IN FUNCTIONAL DYSPEPSIA PATIENTS / 解放军医学杂志

ABSTRACT

Objective To study the relationship between gastrointestinal hormones and gastric emptying in functional dyspepsia (FD) patients. Methods Gastric emptying was assessed with solid radiopaque markers in 54 patients with functional dyspepsia, and then all patients were divided into two groups, one with delayed gastric emptying and the other with normal gastric emptying. 17 healthy volunteers served as normal control group. The plasma NT, MTL, Gas and SS levels (fasting and 30 minutes after meal) were measured by radioimmunoassay (RIA). Results The fasting and postprandial plasma NT levels and the postprandial plasma Gas level were significantly higher in FD group with delayed gastric emptying than those in FD group with normal gastric emptying and in normal control group. The MTL levels in fasting and postprandial plasma were significantly lower in FD group with delayed gastric emptying than those in FD group with normal gastric emptying and in normal control group. The plasma SS levels did not show differences among three groups. Conclusion Gastrointestinal dysmyotonia is closely related to NT, MTL and Gas. NT, MTL and Gas may be important in the pathogenesis of FD.